Annual Lab lunch
Viral vector mediated over-expression of Green Fluorescent Protein (GFP) in dorsal root gnaglion neurons (the cell body of pain-sensing neurons) and nerve fibers
Projection from peripheral neurons are stained in red.
In our laboratory, we focus on understanding the neurobiology of chronic pain. Chronic pain is not simply a continuation of acute pain, the transition from acute to chronic pain requires persisting adaptations that govern the long-lasting plasticity of the nervous system. Improving our understanding of how pain transitions from acute to chronic will facilitate the development of novel disease-modifying drugs. Thereby improving the quality of life of those who suffer from chronic pain. Today, chronic pain affects between 11%–40% of North Americans. Chronic pain drastically impacts the quality of life, is frequently associated with mood disorders and is an expensive public health condition. Our inability to manage chronic pain gave birth to the opioid crisis.
Neurons do not work in isolation; they are constantly interacting with non-neuronal cells. Accumulating evidence suggests that non-neuronal cells such as immune cells, glial cells, keratinocytes, cancer cells, and stem cells play active roles in the pathogenesis and resolution of pain. We are particularly interested by the contribution of non-neuronal cells to the transition from acute to chronic pain.
Activated immune cells release pro-inflammatory factors which sensitize neurons leading to increased pain signaling. Less studied, but likely equally important is the role of anti-inflammatory immune cells in the remission of pain. We are currently investigating the role of the anti-inflammatory cytokine interleukin-10 and its relationship with opioid system in the remission and relapse of neuropathic and postoperative pain.
A second project in the laboratory is the interaction between cancer cells and neurons in a mouse model of Head and Neck Cancer (HNC). HNC is one of the most painful cancers and pain is a predictor of survival. Cancer cells activate “pain-sensing” neurons and induce de novo axon elongation. We are investigating how, and why, cancer cells communicate to “pain-sensing” neurons.
In our laboratory, we use mouse models to decipher the molecular and cellular mechanisms underlying the transition from acute to chronic pain. We model pain states induced by injury, surgery, cancer, inflammation, or chemotherapy treatment to investigate how these insults disturb the interaction between neurons and immune cells and the plasticity of the somatosensory system. To address the contribution of neuro-immune and onco-neuron interactions to chronic pain, we combine molecular, biochemistry, immunostaining, pharmacology, genetically modified mice, viral gene therapy, cell transfer and animal behavior in experimental models of chronic pain.
Geoffroy is an Assistant Professor in the Department of Physiology and the Neuroscience program at Michigan State University. Geoffroy is interested in the contribution of Neuro-Immune interactions to chronic pain development and resolution. He received his PhD degree from the Pasteur Institute / University of Lille in France. He moved to the US to perform his postdoctoral training at MD Anderson Cancer Center under the mentorship of Drs. Hui-Lin Pan, Jean-Pierre Issa, Cobi Heijnen, Robert Danzter, and Annemieke Kavelaars. In addition to research, Geoffroy likes exploring nature, spending family time, and read about European middle ages.
Dr. Joseph Folger got his bachelors and PhD from Cornell University. He then spent 13 years working for Dr. George Smith in MSU’s Department of Animal Science. He worked on numerous projects in female bovine reproduction, primarily focused on the question of what makes a good egg a good egg. Joseph started working for Dr. Laumet in January 2020 and has been learning behavioral assays and an entirely new field of research into chronic pain. Joseph currently manages the lab and the mouse colony and assists with everyone’s projects. For fun, He likes to read, play video games and spend time with my wife, daughter and pets.
Sabrina received a PhD in immunology at the University of Rio de Janeiro in Brazil. She joined the Laumet in February 2022 to investigate the role of immune cells on pain and the contribution of sensory neurons to immunoregulation. In addition to Research, Sabrina mentors undergraduate and junior graduate students in the lab.
Jaewon received her B.S. in biotechnology at Korea University. She started her Ph.D. in Cell and Molecular biology at Michigan State University in 2021. Her research interest is neuroimmune interaction underlying pain. She is studying how immune cells can dampen or aggravate the pain sensation by modifying the neuron as well as the inflammatory environment. In her free time, Jaewon enjoys playing piano, listening to classical music, and watching cute cat videos.
Lizzy O'Guin is a junior undergraduate student studying physiology through the College of Natural Science. She assists with various projects in the lab, including investigating the role of inflammation and IL10 production. After graduation, she plans on attending medical school and specializing in dermatology. In her free time, she enjoys working out, watching sports, learning about true-crime cases, doing art, cooking, and spending time with her friends.
Busola is an undergraduate student majoring in Neuroscience. She assists in the investigation of inflammatory pain. she likes spending times with friends and family.
Hariharan Ramakrishnan is an undergraduate student studying physiology through the College of Natural Science and the Honors College. He joined the lab through a professorial assistantship after winning a full ride through the Honors College alumni distinguished scholarship competition. He assists with various projects in the lab including studies to reduce the toxicity of chemotherapeutic drugs such as cisplatin. After graduation, he plans to attend medical school. At the top of his list of favorite things are sushi, cockatiels, and philosophy journaling. On the weekends, he loves spending time with family and hitting the trails to go mountain biking with friends.
HPV+ head and neck cancer-derived small extracellular vesicles communicate with TRPV1+ neurons to mediate cancer pain. Inyang KE, Evans CM, Heussner M, Petroff M, Reimers M, Vermeer PD, Tykocki N, Folger JK, Laumet G Pain. 2023 Sep 6. doi: 10.1097/j.pain.0000000000003045. Epub ahead of print. PMID: 37678566.
Istradefylline protects from cisplatin-induced nephrotoxicity and peripheral neuropathy while preserving cisplatin antitumor effects. Dewaeles E, Carvalho K, Fellah S, Sim J, Boukrout N, Caillierez R, Ramakrishnan H, Van der Hauwaert C, Vijaya Shankara J, Martin N, Massri N, Launay A, Folger JK, de Schutter C, Larrue R, Loison I, Goujon M, Jung M, Le Gras S, Gomez-Murcia V, Faivre E, Lemaire J, Garat A, Beauval N, Maboudou P, Gnemmi V, Gibier JB, Buée L, Abbadie C, Glowacki F, Pottier N, Perrais M, Cunha RA, Annicotte JS, Laumet G, Blum D, Cauffiez C. J Clin Invest. 2022 Nov 15;132(22):e152924. doi: 10.1172/JCI152924.
T-cell activation state differentially contributes to neuropsychiatric complications in women with HIV. Williams DW, Flores BR, Xu Y, Wang Y, Yu D, Peters BA, Adedimeji A, Wilson TE, Merenstein D, Tien PC, Cohen MH, Weber KM, Adimora AA, Ofotokun I, Fischl M, Turan J, Turan B, Laumet G, Landay AL, Dastgheyb RM, Gange SJ, Weiser SD, Rubin LH. Brain Behav Immun Health. 2022 Aug 29;25:100498. doi: 10.1016/j.bbih.2022.100498. eCollection 2022 Nov.
Infiltration of peripheral immune cells into the olfactory bulb in a mouse model of acute nasal inflammation. Asano H, Hasegawa-Ishii S, Arae K, Obara A, Laumet G, Dantzer R, Shimada A. J Neuroimmunol. 2022 Jul 15;368:577897. doi: 10.1016/j.jneuroim.2022.577897. Epub 2022 May 23.
CD8+ T cell-derived IL-13 increases macrophage IL-10 to resolve neuropathic pain. Singh SK, Krukowski K, Laumet GO, Weis D, Alexander JF, Heijnen CJ, Kavelaars A. JCI Insight. 2022 Mar 8;7(5):e154194. doi: 10.1172/jci.insight.154194.
Prdm12 modulates pain-related behavior by remodeling gene expression in mature nociceptors. Latragna A, Sabaté San José A, Tsimpos P, Vermeiren S, Gualdani R, Chakrabarti S, Callejo G, Desiderio S, Shomroni O, Sitte M, Kricha S, Luypaert M, Vanhollebeke B, Laumet G, Salinas G, Smith ESJ, Ris L, Bellefroid EJ. Pain. 2022 Aug 1;163(8):e927-e941. doi: 10.1097/j.pain.0000000000002536. Epub 2021 Dec 24.
Effects of placebo administration on immune mechanisms and relationships with central endogenous opioid neurotransmission. Prossin A, Koch A, Campbell P, Laumet G, Stohler CS, Dantzer R, Zubieta JK. Mol Psychiatry. 2022 Feb;27(2):831-839. doi: 10.1038/s41380-021-01365-x. Epub 2021 Oct 29.
Can FDA-Approved Immunomodulatory Drugs be Repurposed/Repositioned to Alleviate Chronic Pain? Inyang KE, Folger JK, Laumet G. J Neuroimmune Pharmacol. 2021 Sep;16(3):531-547. doi: 10.1007/s11481-021-10000-z. Epub 2021 May 26.
The µ-δ opioid heteromer masks latent pain sensitization in neuropathic and inflammatory pain in male and female mice. Inyang KE, George SR, Laumet G. Brain Res. 2021 Apr 1;1756:147298. doi: 10.1016/j.brainres.2021.147298. Epub 2021 Jan 29.
Can FDA-Approved Immunomodulatory Drugs be Repurposed/Repositioned to Alleviate Chronic Pain? Inyang KE, Folger JK, Laumet G. J Neuroimmune Pharmacol. 2021 May 26. doi: 10.1007/s11481-021-10000-z. Online ahead of print.
The µ-δ opioid heteromer masks latent pain sensitization in neuropathic and inflammatory pain in male and female mice. Inyang KE, George SR, Laumet G. Brain Res. 2021 Apr 1;1756:147298. doi: 10.1016/j.brainres.2021.147298. Epub 2021 Jan 29.
7β-(3-Ethyl-cis-crotonoyloxy)-1α-(2-methylbutyryloxy)-3,14-dehydro-Z Notonipetranone Attenuates Neuropathic Pain by Suppressing Oxidative Stress, Inflammatory and Pro-Apoptotic Protein Expressions. Khan A, Khan A, Khalid S, Shal B, Kang E, Lee H, Laumet G, Seo EK, Khan S. Molecules. 2021 Jan 1;26(1):181. doi: 10.3390/molecules26010181.
A Novel Syngeneic Immunocompetent Mouse Model of Head and Neck Cancer Pain Independent of Interleukin-1 Signaling. Heussner MJ, Folger JK, Dias C, Massri N, Dahdah A, Vermeer PD, Laumet G. Anesth Analg. 2021 Apr 1;132(4):1156-1163. doi: 10.1213/ANE.0000000000005302.
Nasal administration of mesenchymal stem cells reverses chemotherapy-induced peripheral neuropathy in mice. Boukelmoune N, Laumet G, Tang Y, Ma J, Mahant I, Singh SK, Nijboer C, Benders M, Kavelaars A, Heijnen CJ. Brain Behav Immun. 2021 Mar;93:43-54. doi: 10.1016/j.bbi.2020.12.011. Epub 2020 Dec 11.
CD3+ T cells are critical for the resolution of comorbid inflammatory pain and depression-like behavior. Laumet G, Edralin JD, Dantzer R, Heijnen CJ, Kavelaars A. Neurobiol Pain. 2020 Jan 21;7:100043. doi: 10.1016/j.ynpai.2020.100043. eCollection 2020 Jan-Jul.
Interleukin-10 resolves pain hypersensitivity induced by cisplatin by reversing sensory neuron hyperexcitability. Laumet G, Bavencoffe A, Edralin JD, Huo XJ, Walters ET, Dantzer R, Heijnen CJ, Kavelaars A. Pain. 2020 Oct;161(10):2344-2352. doi: 10.1097/j.pain.0000000000001921.
Interdisciplinary Science & Technology building (ISTB)
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Dr. Laumet is a faculty member in the following training programs. Students in these programs can inquire about rotations in the lab.
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